Neurons dendrite11/9/2023 Nat Genet 23(2):185–188Īndersen R, Li Y et al (2005) Calcium/calmodulin-dependent protein kinase II alters structural plasticity and cytoskeletal dynamics in Drosophila. Science 303(5655):197–202Īmir RE, Van den Veyver IB et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Dev Cell 2(5):525–535Īizawa H, Hu SC et al (2004) Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. This process is experimental and the keywords may be updated as the learning algorithm improves.Īdler PN (2002) Planar signaling and morphogenesis in Drosophila. These keywords were added by machine and not by the authors. We summarize some of the major steps that from developmental transcriptional regulation and environmental information modulate the neuron’s cytoskeleton to obtain the arborized structures that have fascinated neuroscientists for more than a century. Here, we explore the basic mechanisms that lead to the formation of branched dendrites and the cell biological aspects that underlie this complex process. Indeed, inappropriate patterning of dendrites is a common feature of conditions that lead to mental retardation. Establishing appropriate dendrite morphology thus underscores proper neuronal function. The morphology of neuronal dendrites defines the position and extent of input connections that a neuron receives and influences computational aspects of input processing.
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